Fortunately, advanced drug databases serve as powerful computational tools that can connect basic laboratory researchers with the vast array of in silico methods available for drug repurposing. Drug repurposing shows a great deal of promise but it isn’t without its challenges.
According to research, a majority of patients are willing to use recycled drugs if the quality is maintained. Explored requirements for a drug recycling program were examined from the perspective of various stakeholders, including the general public, pharmacists, and policy-makers.
For example, it is helpful to know if medicines being returned are mostly solid-dosage forms and thus have the potential to be reused or are from therapeutic classes that would make medicines reuse cost-effective. Little is known about the therapeutic classes and the dosage forms of wasted medicines.
The review outlines the eminent role of drug repositioning in new drug discovery, methods to predict the molecular targets of a drug molecule, advantages that the strategy offers to the pharmaceutical industries, explaining how the industrial collaborations with academics can assist in the discovering more repositioning opportunities.
In addition, due the different policies for collection and disposal of medicines, the majority of unused medicines were disposed into landfills and water system, which may mean that the returned amount may be underestimate of the extent of unused medicines. The predominant therapeutic group was drugs affecting cardiovascular system.
One of the most exciting prospects of drug repurposing is its potential to tackle "undruggable" targets—proteins or molecules that traditional drugs can't easily bind to. The hope is that repurposing known drugs with already established safety profiles will help to overcome the challenges of undruggable targets.
Towards Medicines Reuse: A Narrative Review of the Different
This practice is potentially a sustainable way of dealing with returned medicines, which are otherwise classed as medication waste and destroyed. To inch towards medicines reuse, it is important to know more about the different therapeutic classes and dosage forms that make up medication waste. For example, it is helpful to know if ...
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Reusing medicines to mitigate their environmental impact
Pharmaceutical waste is a serious threat to both human health and the environment. This article discusses the impact of pharmaceutical waste, and explores the …
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Use of Transdermal Drug Formulations in the Elderly
Transdermal drug delivery systems are pharmaceutical forms designed to administer a drug through the skin to obtain a systemic effect. They ensure a constant rate of drug administration and a prolonged action. Several different types of transdermal delivery devices are available on the market. They are either matrix or reservoir systems and their main current …
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Returning Unused Medications to the Pharmacy? Here''s What …
In the event you can''t find a drug take-back program where it''s possible to visit a pharmacy and give the unused medications back physically, there are still other ways in which such take-back programs can work. The following are a few methods by which drug take-back programs can work, that may not necessarily involve visiting a pharmacy.
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Drug Repurposing: Insights into Current Advances and Future ...
To address this challenge, drug repurposing has emerged as an innovative strategy for finding new uses for existing medications that go beyond their original intended use. This approach …
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Towards Medicines Reuse: A Narrative Review of the Different
This practice is potentially a sustainable way of dealing with returned medicines, which are otherwise classed as medication waste and destroyed. To inch towards medicines …
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A Review: Transdermal Drug Delivery System: A Tool For Novel Drug …
unleachable microscopic drug reservoirs. Figure 10: Cross-sectional view of . Microreservoir dissolution-controlled TDD . systems . This thermodynamically unstable system is quickly . stabilized ...
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Drug Repurposing: A New Life for Old Drugs
One of the most exciting prospects of drug repurposing is its potential to tackle "undruggable" targets—proteins or molecules that traditional drugs can''t easily bind to. The hope is that repurposing known drugs with already established safety profiles will help to overcome the challenges of undruggable targets.
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(PDF) Drug Repurposing: An Emerging Tool for Drug Reuse
The review outlines the eminent role of drug repositioning in new drug discovery, methods to predict the molecular targets of a drug molecule, advantages that the strategy …
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State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug …
Over the past few decades, notable advancements have been made in the field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral drug administration. This comprehensive review aims to enhance understanding of this method by examining various transdermal techniques, the skin''s role as a barrier to TDDS, …
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Intentions to "Reuse" Medication in the Future Modelled and …
However, some countries including the United States (US) and Greece (GIVMED) do operate "medication reuse" schemes, mainly for benevolent reasons—the idea …
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Drug Repurposing: A New Life for Old Drugs
One of the most exciting prospects of drug repurposing is its potential to tackle "undruggable" targets—proteins or molecules that traditional drugs can''t easily bind to. The hope is that repurposing known drugs with …
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Expanding the Application of Drug-Eluting Reservoirs in the Brain ...
pre-existing drug reservoirs can be reused and extend treatment beyond single use . We previously have shown the use of injected small molecules capable of anchoring to ECM in tissue and subsequent capture of circulating molecules even in the brain [2]. However, application of different drugs and other molecules reaching the brain are
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A simple, low cost and reusable microfluidic gradient strategy and …
Such bonding can sustain more than 4 kPa fluidic pressure, which is much more than the required amount for stand-alone microfluidic devices (a reservoir height of > 40 cm can be used). Figure 2 ...
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Design and fabrication of a magnetically actuated non-invasive reusable ...
We present a novel approach of designing and fabricating a noninvasive drug delivery device which is capable of delivering the drug to the target site in a controlled manner. The device utilizes a reservoir which can be reused once the drug has completely diffused from it.
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Intentions to "Reuse" Medication in the Future Modelled and …
However, some countries including the United States (US) and Greece (GIVMED) do operate "medication reuse" schemes, mainly for benevolent reasons—the idea being, briefly, that suitable medicines can re-enter the supply chain and be reissued to …
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disposable infusion pumps
Four parts include filling port (1), drug reservoir (2), movable wall plunger (3), and simple spring (4). The reusable parts of spring pumps are made from materials known for their durability and ...
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Bile Acids Transporters of Enterohepatic Circulation for …
Bile acids (BAs) are important steroidal molecules with a rapidly growing span of applications across a variety of fields such as supramolecular chemistry, pharmacy, and biomedicine. This work provides a systematic …
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Drug recycling
Drug recycling, also referred to as medication redispensing or medication re-use, is the idea that health care organizations or patients with unused drugs can transfer them in a safe and appropriate way to another patient in need. [1]
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Drug Repurposing: Insights into Current Advances and Future ...
To address this challenge, drug repurposing has emerged as an innovative strategy for finding new uses for existing medications that go beyond their original intended use. This approach has the potential to speed up the drug development process and reduce costs, making it an attractive option for pharmaceutical companies and researchers alike ...
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Design and fabrication of a magnetically actuated non-invasive …
We present a novel approach of designing and fabricating a noninvasive drug delivery device which is capable of delivering the drug to the target site in a controlled manner. …
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The Design Features, Quality by Design Approach ...
The drug reservoir can also be created by dissolving the drug and polymer in a common solvent and then evaporating the solvent in a mold at a higher temperature or in a vacuum . The polymer disc, which holds the drug, is then attached to an occlusive base plate within a compartment made of a drug-impermeable plastic backing. The adhesive polymer is …
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