Dopamine Capacitor

What is the gross charge of dopamine?

The gross charge of dopamine therefore varies between -2 and +1, and the molecule exists in 8 different forms when the locations of mobile hydrogens are also considered. Owing to the importance of dopamine, its analytical chemistry and biochemistry have been studied extensively.

How strong is PC-PDA-APS compared to dopamine?

Specifically, the PC-PDA-APS exhibits a much stronger absorption peak around 350 nm than that of dopamine and PC-PDA-O 2, meaning high quinone content in the PC-PDA-APS [ 36, 37 ].

Does dopamine synthesis capacity affect baseline D2/3 binding?

We found a positive relationship between the presynaptic measure of dopamine synthesis capacity and the postsynaptic measure of baseline D2/3 binding. However, relationships between dopamine synthesis capacity and dopamine release were not evident. Below we describe the major implications of these findings and their caveats.

Is dopamine regulation compensatory?

Evidence for compensatory regulation of dopamine function may be most clear in such populations, where the positive relationships between estimated dopamine synthesis and receptor density observed in healthy adults may disappear with disease or show a reversal in their relationship.

How is dopamine transported in the central nervous system?

The transport and reactions of dopamine in the central nervous system are all influenced by the number and location of charges and concomitant acid-base properties. The molecule of dopamine contains one amino and two phenolate sites as basic centers.

What is the protonation constant of dopamine?

The first macroscopic protonation of dopamine can be characterized by a protonation constant of 13.29. This value is in fair agreement with the few literature reports of ca. 13. It can be stated that, with our method of determination, this is the most reliable for such a high protonation constant in the literature so far.