Illinois vs Duke Prediction, Odds, and Pick for Week 2

Illinois enters the matchup with a six-game season-opening winning streak under Bret Bielema. Katin Houser led the offense in Week 1, throwing three touchdown passes, while Ca'Lil Valentine added 88 rushing yards. The Illini are formidable at home, going 13-2 over the past three seasons. forestarrow.rest

Duke, meanwhile, relies on running back Nate Sheppard after a 17-3 win over Tulane. The Blue Devils are without Darian Mensah and have turned to transfer quarterback Walker Eget. Illinois' defense and home advantage are expected to be key factors in Saturday's game.